Berberine HCL CasNo.: 633-65-8 also called berberine hydrochloride, is a derivative of berberine. Berberine is a kind of isoquinoline alkaloids, extracted from the rhizome of Coptis Chinensis (also called Chinese Goldthread). It is yellow powder, soluble in water and hardly soluble in benzene, diethyl ether chloroform or other organic solvents.Berberine powder has a lot of health benefits. In Chinese Traditional Medicine, berberine is used for its antibacterial property, and some studies show that it also has potent antioxidant and anti-inflammatory effects. Many studies show that berberine can significantly reduce blood sugar levels. Berberine may help you lose weight. Berberine can lower cholesterol and may reduce your risk of heart disease.