tert-Butyldimethylsilyl chloride (TBDMS chloride) has several applications in organic synthesis, particularly as a protecting group for hydroxyl groups (-OH). Here are some common applications of tert-Butyldimethylsilyl chloride:
1. Protection of Alcohols: TBDMS chloride is widely used to protect alcohols by converting them into silyl ethers. This protection strategy allows selective reactions to be performed on other functional groups in the presence of the alcohol group.
2. Protection of Phenols: Phenols can be protected using TBDMS chloride to prevent unwanted reactions during synthetic transformations. The silyl protection is stable under various reaction conditions and can be easily removed when desired.
3. Protection of Carbohydrates: Carbohydrates often contain hydroxyl groups that can undergo undesired reactions. TBDMS chloride is commonly employed to protect these hydroxyl groups in carbohydrate chemistry, allowing for selective modifications and transformations.
4. Stereoselective Transformations: TBDMS chloride can be utilized in stereoselective transformations, where the silyl group can influence the regioselectivity or stereochemistry of a reaction.
5. Synthesis of Organosilicon Compounds: TBDMS chloride serves as a precursor for the synthesis of various organosilicon compounds, which find applications in materials chemistry, pharmaceuticals, and agrochemicals.
tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.tert-Butyldimethylsilyl chloride is a derivative of the silylating agent trimethylsilyl chloride (TMSCl) and is commonly used in organic synthesis to protect hydroxyl groups (-OH) in alcohols, phenols, and carbohydrates. It reacts with the hydroxyl group to form a silyl ether, which is stable under various reaction conditions.
Store TBDMS chloride in a cool, dry, and well-ventilated area away from sources of heat and ignition. Keep it tightly sealed in its original container to prevent moisture and air from entering. Store it away from incompatible materials such as water, acids, and oxidizing agents. It’s important to note that TBDMS chloride is a highly reactive compound that can react violently with water or other incompatible materials. It should be handled with extreme care, and appropriate safety measures should be taken when storing or transporting it.
Q:What’s the Minimum Order Quantity of Tert-Butyldimethylsilyl Chloride? A: 1000KG
Q: How to Get Sample of Tert-Butyldimethylsilyl Chloride? A: Sample within 500g could be sent for free once buyer’s DHL account is advised for freight collect or courier cost is paid. The courier cost could be deducted when bulk order is placed.
Q: What is Lead Time of Cas No: 18162-48-6 ? A: Generally, cargo could be loaded on ship in about two weeks after the date of receiving prepayment or L/C. Sometimes one week earlier or later.
Q: What’s the bulk Packing of Tert-Butyldimethylsilyl Chloride? A: In net weight of 25kg/drum.
Q: How about the Tert-Butyldimethylsilyl Chloride of ZXCHEM? A: Tert-Butyldimethylsilyl Chloride, also known as TBDMS chloride or TBDMS-Cl, is a commonly used reagent in organic synthesis for the protection of alcohols, amines, and carboxylic acids.
TBDMS chloride is widely used in organic synthesis as a protecting group for alcohols. It can be used to protect primary, secondary, and tertiary alcohols, as well as phenols. The TBDMS group is stable under a variety of reaction conditions, including acidic and basic environments, and can be easily removed using fluoride ion sources.
In addition to its use as a protecting group for alcohols, TBDMS chloride is also used as a reagent for the protection of amines and carboxylic acids. It is a versatile reagent that can be used in a wide range of organic reactions, including nucleophilic substitution, elimination, and addition reactions.
Overall, Tert-Butyldimethylsilyl Chloride is an important reagent in organic synthesis. Its versatility and stability make it an essential tool for protecting a variety of functional groups in organic molecules.